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PA DOH Patient Advocacy Program Advisory: Increased Risk of Withdrawal Symptoms Associated with 7-hydroxymitragynine (7-OH) and Tianeptine

Last Updated

Sep 11, 2026, 10:28 AM

As you may already be aware, the Drug Enforcement Agency (DEA) has issued two notices of intent to schedule three synthetic 7-hydroxymitragynine (7-OH)-related substances and tianeptine as Schedule I substances.

These recent federal scheduling actions are expected to reduce access to synthetic 7-OH and tianeptine for people across Pennsylvania. Due to disrupted access, individuals currently using 7-OH or tianeptine may experience challenges related to dependence and withdrawal. As a result, physician practices and health care facilities may receive an increase in patient calls or visits related to dependence or withdrawal from these substances. Read More.

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