Transmission of monkeypox requires prolonged close interaction with a symptomatic individual. Brief interactions and those conducted using appropriate PPE in accordance with Standard Precautions are not high risk and generally do not warrant postexposure
prophylaxis (PEP).
Recommendations - Monitoring§
- PEP¶ – Recommended
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Exposure Characteristics - Unprotected contact between a person’s skin or mucous membranes and the skin, lesions, or bodily fluids from a patient (e.g., any sexual contact, inadvertent splashes of patient saliva to the eyes or oral cavity of a person,
ungloved contact with patient), or contaminated materials (e.g., linens, clothing) -OR-
- Being inside the patient’s room or within 6 feet of a patient during any procedures that may create aerosols from oral secretions, skin lesions, or resuspension of dried exudates (e.g., shaking of soiled linens), without
wearing an N95 or equivalent respirator (or higher) and eye protection -OR-
- Exposure that, at the discretion of public health authorities, was recategorized to this risk level (i.e., exposure that ordinarily would be considered a lower risk exposure, raised to this risk level because of unique circumstances)
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| Degree of Exposure: Intermediate |
Recommendations - Monitoring§
- PEP¶ – Informed clinical decision making recommended on an individual basis to determine whether benefits of PEP outweigh risks.¶¶
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Exposure Characteristics - Being within 6 feet for 3 hours or more of an unmasked patient without wearing, at a minimum, a surgical mask -OR-
- Activities resulting in contact between sleeves and other parts of an individual’s clothing and the patient’s skin lesions or bodily fluids, or their soiled linens or dressings (e.g., turning, bathing, or assisting
with transfer) while wearing gloves but not wearing a gown -OR-
- Exposure that, at the discretion of public health authorities, was recategorized to this risk level because of unique circumstances (e.g., if the potential for an aerosol exposure is uncertain, public health authorities may choose
to decrease risk level from high to intermediate)
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| Degree of Exposure: Low/Uncertain |
Recommendations |
Exposure Characteristics - Entered the patient room without wearing eye protection on one or more occasions, regardless of duration of exposure -OR-
- During all entries in the patient care area or room (except for during any procedures listed above in the high-risk category), wore gown, gloves, eye protection, and at minimum, a surgical mask -OR-
- Being within 6 feet of an unmasked patient for less than 3 hours without wearing at minimum, a surgical mask -OR-
- Exposure that, at the discretion of public health authorities, was recategorized to this risk level based on unique circumstances (e.g., uncertainty about whether Monkeypox virus was present on a surface and/or whether a person
touched that surface)
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| Degree of Exposure: No Risk |
Recommendations - Monitoring§ – None
- PEP¶ – None
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Exposure Characteristics - Exposure that public health authorities deemed did not meet criteria for other risk categories
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Abbreviations: PEP = postexposure prophylaxis
§ Monitoring includes ascertainment of selected signs and symptoms of monkeypox: fever (≥100.4°F [≥38°C]), chills, new lymphadenopathy (periauricular, axillary, cervical, inguinal), and new skin rash through 21 days after the exposure to the patient or the patient’s materials. Monitoring could involve in-person visits, regular communications (e.g., phone call or another system) between public health representatives and the person under monitoring, self-monitoring by persons and reporting of symptoms to health departments only if symptoms appear, or another reliable system determined by the health department. Health departments should take into consideration the person’s exposure risk level, the number of persons needing monitoring, time since exposure, and available resources, when determining the type of monitoring to be conducted. Persons should be advised to self-isolate if any symptoms develop. Persons who report only chills or lymphadenopathy should remain at their residence, self-isolate for 24 hours, and monitor their temperature for fever; if fever or rash do not develop and chills or lymphadenopathy persist, the person should be evaluated by a clinician for the potential cause. Clinicians can consult with the state health department if monkeypox is suspected. If a fever or rash develops, CDC should immediately be consulted.
¶ ACAM2000 and Jynneos are available for PEP.
¶¶ PEP can be considered for contact through activities such as assistance with bathing, dressing, transferring, or other activities.